杨宇
博士生导师 | 研究员
招生专业
肿瘤学
研究领域
细胞表面DNA分子工程、核酸生物材料、免疫工程、精准免疫治疗、纳米生物技术
导师简介
杨宇，上海交通大学医学院分子医学研究院研究员、博士生导师。入选国家海外优青和上海市海外高层次人才计划。博士毕业于澳门大学生物医药专业，随后在美国佛罗里达大学谭蔚泓院士课题组从事分子医学领域的博士后研究。近年来，他以临床需求为导向，致力于发展基于长链核酸的肿瘤与免疫微环境干预技术及相关治疗方法。近5年来，以第通讯作者在Chem（3篇）、Sci. Adv.（2篇）、J. Am. Chem. Soc.（4篇）、Angew. Chem. Int. Ed（2篇）、Adv. Mater. （2篇）、Nano Lett.（2篇）、ACS Nano（2篇）、ACS Cent. Sci.（2篇）等国际高水平学术刊物上发表SCI文章30余篇。论文总引用7000余次，H因子42，多篇论文入选 “ESI高被引论文”。主持国家重点研发计划课题、国自然面上、青年基金等；获得上海市曙光学者（2024）、澳门科技奖研究生科技研发奖（2018）、Baxter China青年研究者奖一等奖（2019）；担任中国生物材料学会青年委员会委员、世界中医药学会联合会中药药剂委员会理事，并担任Nano Micro Letters、Exploration和AJPS等期刊青年编委。
课题组网站：http://www.yanglab.com.cn
社会任职及获奖：
2024— 上海市曙光学者
2023— 中国生物材料学会青年委员会委员
2023— Nano-Micro Letters 青年编委
2023— Exploration 青年编委
2023— Asian J. Pharm. Sci. 青年编委
2022—2026 中国超声医学工程学会分子影像超声专委会委员
2022 上海科技青年35人引领计划入围终评100人
2019 Baxter China青年科学家奖一等奖
2018 澳门科技奖研究生科技研发一等奖
2018—2022 世界中医药学会联合会中药药剂委员会理事
代表性论文：
13. Jingqi Chen; Yuqing Li*; Xueliang Liu; Hongyi Li; Jiawei Zhu; Rui Ma; Linxin Tian; Lu Yu; Jiabei Li; Zhuang Liu; Weihong Tan; Yu Yang*. Antigen Spatial Matching Polyaptamer Nanostructure to Block Coronavirus Infection and Alleviate Inflammation. Chem (Cell Press), 2025, 11, 1-12.
12. Dongsheng Mao; Wenxing Li; Xueliang Liu; Jingqi Chen; Dali Wei; Lei Luo; Qianqin Yuan; Yu Yang*; Xiaoli Zhu*; Weihong Tan. Rolling circle amplification-based DNA-enzyme nanostructure for immobilization and functionalization of enzymes. Chem (Cell Press), 2025, 11, 1-13.
11. Shuang Wang#, Xueliang Liu#, Dali Wei#, Huayuan Zhou, Jiawei Zhu, Qing Yu, Lei Luo, Xinfeng Dai, Yiting Jiang, Lu Yu, Yu Yang*, Weihong Tan*. Polyvalent Aptamer Nanodrug Conjugates Enable Efficient Tumor Cuproptosis Therapy through Copper Overload and Glutathione Depletion, Journal of the American Chemical Society, 2024, 146(44): 30033-30045.
10. Yuting Huang#, Xueliang Liu#, Jiawei Zhu#, Zhejie Chen, Lu Yu, Xin Huang, Chuhuang Dong, Jiabei Li, Huayuan Zhou, Yu Yang*, Weihong Tan. Enzyme core spherical nucleic acid that enables enhanced cuproptosis and anti-tumor immune response through alleviating tumor hypoxia, Journal of the American Chemical Society, 2024, 146(20): 13805-13816. (Cover Paper)
9. Dongsheng Mao#, Ziliang Dong, Xueliang Liu, Wenxing Li, Hongyi Li, Chao Gu, Ganghui Chen, Xiaoli Zhu*, Yu Yang*. An Intelligent DNA Nanoreactor for Easy-to-Read In Vivo Tumor Imaging and Precise Therapy, Angewandte Chemie International Edition, 2024, 63(7):e202311309.
8. Xueliang Liu#, Binghua Chen#, Jingqi Chen#, Xuan Wang, Xinfeng Dai, Yuqing Li, Huayuan Zhou, Lianming Wu*, Zhuang Liu*, Yu Yang*. A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction, Advanced Materials, 2024, 36(2):2308477.
7. Xueliang Liu#, Fan Li#, Ziliang Dong, Chao Gu, Dongsheng Mao , Jingqi Chen, Lei Luo, Yuting Huang, Jie Xiao*, Zhanchun Li*, Zhuang Liu*, Yu Yang*. Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment, Science Advances, 2023, 9(31), eadf3329. Highlighted by Nat. Rev. Rheumatol. 2023,19, 606.
6. Yuqing Li#, Xueliang Liu#, Lu Yu, Xin Huang, Xuan Wang, Da Han*, Yu Yang*, and Zhuang Liu*. Covalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy, Journal of the American Chemical Society, 2023,145, 45, 24506–24521.
5. Chao Gu#, Xueliang Liu#, Lei Luo, Jingqi Chen, Xiao Zhou, Ganghui Chen, Xin Huang, Lu Yu, Qian Chen, Yu Yang*, and Yang Yang*. Metal-DNA Nanocomplexes Enhance Chemo-dynamic Therapy by Inhibiting Autophagy-Mediated Resistance, Angewandte Chemie International Edition, 2023, 62(50):e202307020.
4. Xiaohao Liu#, Dongsheng Mao#, Yuchen Song, Liucun Zhu, Albertina N Isak, Cuicui Lu, Guoli Deng, Feng Chen, Fenyong Sun*, Yu Yang*, Xiaoli Zhu*, Weihong Tan*. Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. Science Advances, 2022, 8(2), eabk0133.
3. Yu Yang, Jun Xu, Yang Sun, Liuting Mo, Bo Liu, Xiaoshu Pan, Zhuang Liu*, Weihong Tan*. Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy. Journal of the American Chemical Society, 2021, 143, 22, 8391–8401.
2. Yu Yang, Zhuang Liu*. Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy. Chem (Cell Press), 2020, 6 (9): 2127-2129.
1. Yu Yang, Wenjun Zhu, Ziliang Dong, Yu Chao, Lai Xu*, Meiwan Chen*, Zhuang Liu*. 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy. Advanced Materials (Cover Paper), 2017, 29(40).